Fatima Zohra Choumane
Dr Tahar Moulay university, Algeria
Application of coagulation- flocculation process for wastewater using potato residues
Fatima Zohra Choumane is a Senior Lecturer HDR at Dr Tahar Moulay university, Algeria. She has done her PhD in Science, speciality: Chemistry and Environnent, University of Tlemcen. Algeria, Her research activities are focused on petrochemistry, Thermodynamics, municipal solid Waste, unit operations, renewable energy, recovery of peanut by products, the industrial safety and combating pollution, structure of matter, practical work of chemistry of waters, chemical engineering and physical chemistry
Application of coagulation- flocculation process for wastewater using potato residues
The present paper focuses on coagulation - flocculation technology for wastewater treatment of Saida in Algeria using Jar Test. The efficiency of the process is evaluated by the measure of the turbidity. A better efficiency of the treatment without addition of the flocculant is obtained after an increase in the copper sulphate coagulant dose with an optimal shaking time of 60 min; 99.87% removal turbidity was obtained for a mass 2 g of coagulant. The follow-up of the process in the presence of flocculant potato peel showed that an efficiency of the process can be achieved by an increase of the dose of potato peel flocculant up to 0.5g. The removal efficiency obtained is in the order of 100%. In addition, the examination of the physicochemical parameters recorded, after the waste water has undergone flocculation tests shows that the degree of pollution is reduced. This is confirmed by the levels turbidity obtained to 100%, and by the reduction of the content in BOD5 from 317.03 mg of O2 / l to 5 mg of O2 / l with a reduction of 98%.
Dr Tahar Moulay university, Algeria
Study of liquid-liquid extraction of Cadmium by the mixture of ALIQUAT336 /TBP
ZAOUI FATIHA is a Senior Lecturer HDR at Dr Tahar Moulay university, Algeria. She has done her PhD in Science, speciality :Catalysis and Environnent, University of Tlemcen. Algeria Her research activities are focused on Thermodynamics, municipal solid Waste, unit operations, renewable energy, recovery of peanut by products, the industrial safety and combating pollution, structure of matter, practical work of chemistry of waters, CATALYSIS , Heavy metal treatement
This work concerns the liquid-liquid extraction of Cd (II) in nitrate medium by mixture of the Aliquat 336 / TBP in well-defined proportions. Various parameters were optimized such as the contact time (30 minutes), the concentration of the aqueous phase (10 -3 M), the volume ratio between the volume of Aliquat 336 and TBP (Q = 1), the effect of pH and the effect of salt. The thermodynamic study has shown that the extraction process is spontaneous (ΔG <0) and exothermic (ΔH <0). On the other hand the effect of the addition of iron (III) has a considerable influence on the extraction of cadmium.
Hiroshima University, Japan, Japan
Improvement in the survival rate of freeze-dried lactic acid bacteria with the addition of a disaccharide-antioxidant mixture
KiyoshiKawai has his expertise in processing, preservation, and sensory analysis for biomaterials and food products. He has many techniques for the analysis of thermal and rheological properties.This approach is especially useful for the determination of glass transition temperature of the complex materials.
Some kinds of lactic acid bacteria (LAB) are destabilized during freeze-drying and subsequent storage. Stabilizing effect of various protectants on the freeze-dried LAB, therefore, has been investigated intensively. Specific animals such as tardigrade and chironomid have a large amount of disaccharides (sucrose and/or trehalose) in the dehydrated state and survive. In addition, sucrose and trehalose play a role of effective protectant for dehydrated biomaterials. More recently, it was found that a leech capable could survive at the extremely low temperature. Furthermore, the leech has a large amount of antioxidant such as carnosine after the freeze-thawing. Taking this into account, there is a possibility that carnosine plays a role of stabilizer to freeze-dried LAB. The purpose of this study was to understand effect of sucrose, carnosine, and their mixture on the survival rate of freeze-dried LAB.
Lactobacillus reuteri JCM 1112T (L. reuteri) were provided from RIKEN BioResource Center, Japan. Antioxidants such as carnosine, sucrose, and their mixtures were dissolved in PBS, and mixed with the LAB suspension (1×1010 CFU/ml). The formulations were freeze-dried, and stored in various water activity conditions (0.11~0.85) at 25 ºC for 4 weeks. Survival rate of LAB was evaluated after the storage.
There was no or very little reduction of survival rate for control (non-additive sample) after freeze-drying, but decreased drastically after storage. The control sample showed a relatively high survival rate at water activity = 0.11, but the survival rate remarkably decreased at a higher water activity. Carnosine and sucrose samples showed higher survival rate than control at water activity = 0.11, and decreased with increase in water activity. The carnosine-sucrose sample showed the best stabilizing effect among the samples. These results were discussed based on the “water substitution” and “glass transition” concepts.
SKEDERM cosmetic R&D center, South Korea
Optimization of high ultrasound-assisted extraction(INEFU) of active components from natural materials by response HPLC-PDA analysis
High ultrasonic-assisted extraction technology(INEFU) was employed to extract the active components from natural materials (Green coffee bean, Citrus madurensis, Centella asiatica, Laminaria Japonica). The extraction conditions were optimized by response surface method and Box-Behnken design. The active component yields were obtained under the optimum parameters: ultrasound power 1800W, ultrasound time 42 min, and particle size 80 mesh. After INEFU by natural materials (Green coffee bean, Citrus madurensis, Centella asiatica, Laminaria Japonica) were analyzed with high performance liquid chromatography (HPLC). HPLC analysis showed that four natural materials were composed of difference combination of Vitamin C, Polyphenol, Chlorogenic acid, Caffein, Caffeic acid, Asiaticoside, Alginic acid. In addition, A method for the analysis of natural materials (Green coffee bean, Citrus madurensis, Centella asiatica, Laminaria Japonica) belonging to different classes has been developed and validated. The analyses were performed by HPLC–PDA directly after INEFU and HAE extracts for natural materials and after freeze dryer for five important active index component. The method was fully validated and applied to the analysis of active index component in samples from natural materials. Natural materials varieties and one well-known international cultivar, Wonderful. The method allowed qualitative and quantitative analysis of the principal active index component in the different extract methods (INEFU and HAE) of Green coffee bean, Citrus madurensis, Centella asiatica, Laminaria Japonica. Differences in active index component profile and concentration can be evidenced, allowing green coffee bean, Citrus madurensis, Centella asiatica, Laminaria Japonica to be distinguished on the basis of the concentration of compounds from INEFU extract methods.
Mark I. Mosevitsky
Kurchatov Institute, Russia
Brain extracellular peptidases and design of stable enkephalin modifications providing long-term analgesia
Mark I. Mosevitsky is graduated from Leningrad Polytechnic Institute as an engineer-physicist in the field of polymers. Several years he worked in Prof. I. Poddubny lab. in the field of physical chemistry of synthetic rubber. Then he went to the lab of Biological polymers founded by Prof. S. Bresler. He also work there till now as Head of research group and studied genetic processes in bacteria (1), chromatin composition (2), brain proteins (3), brain extracellular peptidases (4), stabilization of therapeutic peptides (5) etc.
In brain, a group of weakly bound to neurons extracellular metallopeptidases (NEMP) is present (E. Kropotova, M. Mosevitsky. Neurochem. Res., 2016, 41, 2666-2674). It contains carboxypeptidase NEMP1 and aminopeptidase NEMP2, which can be responsible for rapid degradation of exogenous peptides introduced in brain. It was found that these enzymes are unable to break the peptide bonds formed by β-alanine. Keeping in mind this finding, we designed several modifications of opioid peptide enkephalin (Tyr-Gly-Gly-Phe-Met). The modifications carrying the β-alanine residues at the ends(βAla-Tyr-Gly-Gly-Phe-Met-βAla and βAla-Tyr-Gly-Gly-PheNH2) showed high stability in the synaptosome suspension that mimics extracellular medium of the brain. These stable enkephalin modifications were tested in standard “pain” experiments on rats with intranasal peptide administration. Both “stable” modified forms have fully preserved anesthetic efficiency of enkephalin, but it is highly prolonged. Taking into account non-toxicity of β-alanine and the simple structure of created enkephalin modifications, it should be assumed that described modifications have a good chance to become a promising anesthetic drugs. This work was supported by Russian Basic Investigations Foundation (grants 09-04-01571-a and 12-04-00505-a and 14-04-00587-? (to M.I. Mosevitsky)
University of Wollongong, Australia
NEW APPROCHES FOR ADVANCED LITHIUM-SULFUR BATTERS
Jiazhao Wang is a Professor at the Institute for Superconducting and Electronic Materials, University of Wollongong, Australia. Her research activities are focused on electrochemical energy storage in batteries, including Li-ion batteries, Na-ion batteries, metal-air batteries (Li-air, Na-ion Zn-air batteries), and Li-S batteries. She has won 28 research grants including 19 Australian Research Council (ARC) grants as a chief investigator (CI). She is solo CI, first CI and APD fellow for 4 ARC Discovery Projects (DP) and 3 ARC Linkage Projects (LP). She is current a team leader of an ARC DP on Na-air batteries, and a team leader of an ARC LP on Li/S batteries. She has published more 200 papers in international journals (Citations>15000, H index = 68, Google Scholar, Dec. 2018). She is highly 2018 Highly Cited Researcher (Highly Cited Researcher is among an elite group recognized for exceptional researchperformance demonstrated by production of multiple highly cited papers that rank in the top 1% by citations for field and year in Web of Science) She has supervised 30 PhD students. She has also been invited to deliver more than 60 keynote/invitedtalks/seminars worldwide. She is currently acting as editorial board member of Applied Science. She is a regular referee for more than 50 international prestigious journals.
Recently, much attention has been directed towards using elemental sulfur and sulfids for the development of green, low-cost and high-energy-density rechargeable lithium batteries. The Li–S battery is a very attractive energy storage system owing to its high theoretical specific capacity of 1672 mAh g−1 and theoretical power density of 2600 Whk g−1. Sulfur-carbon composites were synthesised using vapor-phase infusion method, wet chemical precipitation, ball-milling and spray-pyrolysis/sublimation methods[2–3]. Sulfur-conducting polymer composites were also prepared with electropolymerization method . The composites were investigated as cathode materials for Li/S batteriesin our group. A free-standing sulfur-polypyrrole cathode and a PPy coated separator were designed for flexible Li-S batteries. The free-standing sulfur-polypyrrole cathode was prepared by directly pasting a sulfur-coated polypyrrole nanofiber composite on a flexible PPy film. Compared with carbonaceous matrixes, PPy has a strong interaction with polysulfides to mitigate the dissolution of polysulfides. In addition, the as-prepared PPy film possesses a rough surface, which can accommodate volume expansion, enhance the adhesion of active materials, and further trap the dissolved polysulfides. In order to further improve the cycling stability of Li-S batteries, a PPy coated separator was prepared, which acts as a fishing net to capture polysulfides and alleviate the shuttle effect. Considering the flexibility of the free-standing sulfur cathode and PPy coated separator, a soft-packaged flexible Li-S battery based on them has been designed and fabricated to power a device consisting of 24 light emitting diode (LED) lights. After repeated bending, the flexible Li-S battery can still maintain good performance, indicating the excellent mechanical flexibility of the designed Li-S battery .
NiS and MoS2were also synthesized and investigated for rechargeable lithium batteries
Saif Al Ghafri
University of Western Australia, Australia
Solid-Liquid and Vapor-Liquid Equilibria of BTEX Compounds in Methane and Ethane Mixtures at LNG Conditions
Dr Saif Al Ghafri is a postdoctoral research fellow at UWA working in the Thermophysical properties measurements. He obtained his PhD in 2013 on Carbon Capture and Storage (CCS) from Imperial College London, focusing on measurements of the Thermophysical properties of mixtures of carbon dioxide with reservoir fluids. Dr Al Ghafri worked as a postdoctoral research associate at Imperial College for two years before joining UWA. He is currently involved in different LNG projects within the Fluid Science and Resources (FSR) group including vapor-liquid equilibrium, viscosity, solid-liquid equilibrium, density, bubble points and boil-off gas measurements.
The formation and deposition of solids during the cryogenic processing of natural gas is a perennial risk for operators. If present in high enough quantities, heavy hydrocarbons including BTEX (benzene, cyclohexane, toluene, p-xylene and ethyl-benzene) aromatics and paraffins (n-hexane to n-decane) can lead to freeze-out problems in the cryogenic heat exchanger. A lack of experimental data for the solubility of such heavy hydrocarbons in LNG limits the accuracy of predictive engineering models used to avoid such problems. Moreover, data for the partitioning (VLE) of BTEX compounds, which exist as minor components in both phases, are particularly important given the freeze-out risk they pose for the downstream main cryogenic heat exchanger. Thus, in addition to the SLE data, high-quality VLE data for LNG-related mixtures are essential for improving and examining the accuracy of existing equations of state (EOS) used in the design and simulation of the cryogenic distillation columns, also known as scrub columns.
In this work, a specialized apparatus designed for visual measurements of solid-liquid equilibrium (SLE) was used to measure liquidus (melting) temperatures in binary mixtures of methane/ethane + p-xylene and methane + n-decane at varying compositions and pressures up to 30 MPa. Solid-liquid equilibrium data for p-xylene + methane were measured for the first time at compositions ranging from 0 < xC1< 0.52 at pressures to 28 MPa. Melting conditions for p- xylene + ethane mixtures were measured at compositions from 0 < xC2< 0.95 at temperatures down to 200.8 K. Predictions made using the Peng-Robinson EOS as implemented in industry-standard software under-estimated the melting temperatures of methane + p-xylene by over 8 K while for ethane + p-xylene, the melting temperatures were over-predicted by over 30 K. Melting temperatures of methane + decane systems were also measured down to 233.7 K at xC1 = 0.834 and p = 23 MPa.
Furthermore, an analytical apparatus, fitted with a GC for compositional analysis, was used to measure the vapor-liquid equilibrium of a ternary methane + propane + methylbenzene (toluene) and methane + propane + 1,4-dimethylbenzene (p-xylene) mixtures over a wide range of conditions, with toluene and p-xylene as the minor components in both the liquid and vapor phases. Measurements were conducted at temperatures between (213 and 323 K) and at pressures up to 12 MPa. The measured VLE data were compared to values calculated with the Groupe European de RechercheGaziere (GERG-2008) multiparameter EOS and the HYSYS Peng Robinson (PR) equation of state (EOS) used widely in the LNG industry. The amount of toluene and p-xylene in the vapor phase was under-predicted by both EOS, with the deviations increasing in magnitude at low temperatures. These VLE measurements demonstrate that current EOS substantially under-predict the possible BTEX content of saturated vapors that could be present in the overhead product stream of an LNG scrub column
University of Gabès, Tunisia, Tunisia
Treatment of urban wastewater effluent by advanced electrochemical oxidation using platinium electrode
Researcher in Chemistry
Advanced electrochemical oxidation has attracted large attention as one of the environmental-friendly technologies used in the wastewater treatment field. The present research was carried out using a secondary wastewater effluent produced by a treatment plant which employs activated sludge process. The main purpose of this study was to determine the depuration efficiencies of anodic oxidation on platinium electrode to remove contaminants from urban wastewater. Removal efficiencies of organic matter expressed in terms of chemical and biochemical oxygen demand (COD, BOD), ammonium nitrogen (NH4-N), nitrate nitrogen (NO3-N) and orthophosphate (PO4-P) were investigated. Experimental results indicated that the elimination of these pollutants was shown to mainly depend on both the applied current intensity and operating time. The best removal rates were obtained after three hour oxidation and with a current intensity of 1000mA. Total elimination of ammonium nitrogen, nitrates and orthophosphate was obtained.
Alex Ekwueme Federal University, Nigeria
OPTIMIZATION OF ADDED CALCITE IN LIME COMPOSITE CEMENT
Researcher in chemistry
The consistency, setting time and twenty eight (28) days compressive strength of lime composite cements with 5, 10, 15, 20, 25 and 30% limestone content were investigated and compared with those of Ordinary portland cement (specify the ordinary Portland cement)(32.5 MPa) in order to determine the optimum lime content for high quality lime composite cement. Test results indicated that setting times of lime composite cement blends increased while consistency decreased with increased lime addition. The 28 days compressive strength of mortars of lime composite cements above 15% added lime varied significantly from that of Ordinary portland cement (p<0.05), while those of lime composite cement blends containing 5 – 15% added lime compared favourably with Ordinary portland cement (p>0.05) indicating that cheaper cement of quality comparable with Ordinary portland cement could be obtained with addition of 5 – 15 % lime to clinker. Thus, cheaper cement of comparable quality as Ordinary portland cement can be obtained with lime content not exceeding 15 %. Moreover, they are cheaper in production cost and concrete works.
Informatics and material sciencesUniversity , Algeria
Quantum chemical electronic structure and structure activity investigation of vanillin and ?-cyclodextrin
Gharibi Meryem is a Resercher in Chemistry from Informatics and material sciences university, Algeria.
In this work,through computational study based on density functional theory (DFT/B3LYP)using basis set 6-311g++(d,p) a number of global and local reactivity descriptors were computed to predict the reactivity and reactive sites on molecules .
the molecules geometry and the electronic properties such as frontier molecule orbital (HOMO and LUMO).
from the NBO calculation, the van der Waals force and electronic interactions are the major factors contributed to the overall stabilities of the complexation.
Keywords: Vanillin, B-CD, DFT, NBO
Université Djillali LIABES, Algeria
Theoretical mechanistic study of the bromination of glutaconaldehyde benzoyl ester.
Researcher in Chemistry
Glutaconaldehyde benzoyl ester is a bifunctional reagent where more than one site can be attacked, and, as such, a potential precursor for various heterocyclic compounds . The present study is a theoretical investigation of the bromination reaction of glutaconaldehyde benzoyl ester. This reaction was experimentally found to be regiospecific . It will be sufficient, in this study, to focus attention to the dyanamic approach of the chemical reactivity. Indeed, the transition state theory was applied in order to gain mechanistic insight of the bromination reaction of glutaconaldehyde benzoyl ester. The stationary points on the reaction potential energy profile including intermediates and transition states were successfully located employing hybrid DFT procedure at the B3LYP/6-31G* level of theory. The bromination proceeds in two steps. Initially, a π-complex forms between bromine molecule and glutaconaldehyde skeleton . Further the π-complex with high activation barrier transforms to σ-complex intermediate. Finally the σ-complex transforms to product brominated glutaconaldehyde benzoyl ester. The predictions thus made are in a good agreement with experimental results.
Mohammad Wasi Ahmad
Dhofar University, Oman
Biocompatible Ligands Coated Nanoparticles for MRI Contrast Agent
Researcher in Chemistry
Magnetic resonance imaging (MRI) is widely used in modern clinical medicine as a diagnostic tool, and provides noninvasive and three-dimensional visualization of biological phenomena in living organisms with high spatial and temporal resolution. Therefore, considerable attention has been paid to magnetic nanoparticles as MRI contrast agents.
We report a facile method to synthesize high quality and bio-functionalized Gd2O3 nanoparticles (BFNPs) for use as contrast agents in MRI. The bonding status of BFNPs were confirmed by FT-IR and TGA analysis. The surface coating amount was estimated to be from 40% to 60% in weight percent from a TGA analysis. High voltage electron microscope (HVEM) shows that the BFNPs were spherical in shape with an average diameter 3 mM. In addition, the bio-compatibility of the nanoparticles were measured by cytotoxicity tests by using human prostate cancer (DU145) and normal mouse hepatocyte (NCTC1469) cell lines which indicated that BFNPs are not toxic up to 250mM. BFNPs are paramagnetic but have an appreciable magnetic moment at room temperature. This is because Gd(III) has seven unpaired 4f-electrons (S = 7/2). Therefore, appreciable r1 and r2 values are expected from sample solutions, which were in fact observed in this study. The r1 and r2values of BFNPswere estimated to be 13.77 to 64.14 s -1 mM -1respectively. The high relaxivities provide an opportunity to conduct perfusion MRI experiments with significantly lower concentrations than those needed for current commercial agents. A pronounced positive and negative contrast enhancement was clearly observed in 3 tesla T1 MR images of a rat with a liver tumor after injection of an aqueous sample solution into a rat tail vein.
American University of Beirut, Lebanon
SYNTHESIS, STRUCTURAL EVOLUTION AND APPLICATIONS OF METAL ORGANIC FRAMEWORK AND ZEOLITIC IMIDAZOLATE FRAMEWORKS
Researcher in Chemistry
Metal-Organic Frameworks (MOFs) and ZeoliticImidazolate Frameworks( ZIFs) are an incipient class of highly crystalline porous extended frameworks.These materials are characterized by their hybrid identity as they are formed by anchoring organic linkers mainly containing carboxylate (for MOFs) and Imidazolates (for ZIFs) moieties with metal clusters via strong coordination bonds. These materials are renowned by their ultrahigh porosity, high surface area, flexibilityand good thermal stability overcoming zeolites, activated carbons and other ordinary porous materials.Traditionally, MOFs and ZIFs are prepared through solvothermalmethods, but alternative synthetic strategies have been developed based on exploiting conventional electric or microwave heating, electrochemistry, mechanochemistry, and ultrasonication. Herein, we exploit a new method of synthesizing MOFs and ZIFs via a reaction diffusion process at room temperature .Our novel method of synthesis is advantageous in that it can be easily carried out under facile conditions and provides control of the morphology and the size of the crystals by adjusting the thickness of the gel, the concentrations of the electrolytes and temperature. Moreover, more than one kind of metals and/or ligands could be incorporated within the same topology. Furthermore, application of these new materials on adsorption and catalysis are investigated and discussed.
Assiut University, Egypt
A Smart Chemosensor: Discriminated Multidetection and Execution of Various logic Gates in Aqueous Solution at Biological pH
Awad syed is a researcher in chemistry from , Assiut University, Bulgaria, Egypt
A novel rhodamine and pyrazole based probe was designed and easily synthesized. The probe could to detect several analyts in aqueous solution at biological pH (HEPES, 7.2). the probe could to detect discrimintly Several catoions, including Cu2+, Fe3+, Al3, Hg2+ and Ni2+. The detection could be selective towards Cu2+ by using high concentration of HEPES (10-3 M-1) in aquous solution and could be selective towards Hg2+ (by absorption spectrum) by working in pure organic medium (acetonitrile). By low concentration of HEPES buffer and one equivalent of cation, Fe3+ was discrimined by the enhancement of both the absorption at 530 nm and emission at 560 nm, but Al3+ enhanced the emission at 560 nm remarkably (high quantum yield). Ni2+ could to be discriminated by increaing both absorption and emission after using ten equivalents of Ni2+ and low concentration of HEPES (10-5 mole L-1). Also, the probe exhibited a good selectivity towards S2O52- by both absorption and emission spectra. Moreover, probe-Cu2+ complex could to detect several anions, including F-, CN-. S2-, CH3COO-, CO32-, NO2-. A further exploition of the prepared probe, is its ablility to work as a molecular logic gate to perform many gates including AND, NAND, NOR and INHIBIT logic gates.
University of Sarajevo, Bosnia
THE EVALUATION OF SERUM TUMOR MARKERS CA 15-3 AND CEA IN BREAST CANCER
NafijaSerdaderevic, PhD is Associate professor at Faculty of health study Sarajevo, University of Sarajevo, and Faculty of Pharmacy in Tuzla Bosnia and Herzegovina. She is working at Department of Clinical Biochemistry and Immunology, Clinical Center University of Sarajevo Bosnia and Herzegovina. She obtain her PhD thesis” Serum concentration of homocystein after stroke” at Faculty of Pharmacy in Tuzla Bosnia and Herzegovina. She had successfully completed her Master's degree in pharmacy (field of clinical biochemistry) at the Faculty of Pharmacy, University of Ljubljana in 2004.She completed her studies with an average mark of 9.4. The topic of her thesis was Determination of lithium ions in body fluids. The thesis was carried out in General Hospital Ptuj and in Clinical Center University of Sarajevo (Bosnia and Herzegovina).
Statement of the Problem: Cancer can be detected and monitored using biologic tumor markers. Tumor markers are produced either directly by the tumor or as an effect of the tumor on healthy tissue. Ideally, a tumor marker would be tumor specific, absent in healthy individuals, and readily detectable in body fluids. CA 15-3 and CEA are the markers most widely used for surveillance purposes and monitoring of treatment response in clinical practice of breast cancer. In the study we investigated level of tumor markers in patients with the diagnosis of breast cancer before and after completed surgery during a one year. Methodology & Theoretical Orientation: Serial serum values of CA 15-3 and CEA were determined in 60 patients with recurrence after breast cancer. Also, we have control group of 60 subjects with the cut off of tumor markers CEA (0-5 ng/mL) and CA 15-3 (0-31,3 U/mL). The study included 120 women patients who were hospitalized at the Oncology Clinic and laboratory tests were investigated at Institute for Clinical chemistry in University Clinical Centre.
The serum concetration of tumor markers were measured CA 15-3 using electro chemiluminescence (ECL) COBAS E601 (Roche) and CEA using Intellicheck Technology Vitros 5600. Findings:The increase of tumor markers CEA and CA 15-3 is occuring during ilness advancing. There is positive correlation between CEA and CA 15-3. Statistical analysis of sensitivity and specifity of tumor markers CEA and CA 15-3 per devision healthy/sick respondents have shown us that sensitivity of exament parameters CEA ≈33.1% and CA 15-3 ≈36.7%. Elevated CA 15-3 level was correlated with bone metastasis (P=0.017). However, elevation of CEA was observed regardless of the site of metastasis. Conclusion & Significance: Serum biomarkers such as CA 15-3 or CEA may be used in monitoring therapy in patients with advanced disease receiving systemic therapy.
King Saud University, Saudi arabia
Modulating the DNA Repair Pathway Gene Expression in Breast Cancer Cells by Curcumin Analog (PAC)
Esra Almalki is a resercher in chemistry from King Saud University, Saudi Arabia
Background:Breast Cancer (BC) is a multifactorial disorder with genetic alteration and environmental factors as well as the most commonly diagnosed life-threatening malignancy in females. Moreover, even if there is development in BC treatments till date, there are still limitations in the efficiency of these treatments. To this end, scientists try to revisit tradition medicine, and attention has been drawn to natural products such as curcumin and their analogs due to their anti-cancer effect and their safety. In the present study, we investigated the effect of Curcumin analogs 3,5-Bis (4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone(PAC) on the DNA repair pathway in human breast cancer cells.
Methods:In vitro cultures of human MCF-7 and MDA-MB231 were exposed to PAC. Subsequently, DNA repair signaling pathways were evaluated by PCR Arrays focused on genes related to DNA repair pathway, and we confirmed the PCR array results by RT-PCR.
Results:Curcumin analog (PAC) affected the expression of multiple genes involved in the DNA repair pathway in breast cancer cell line. Our results indicate that PAC observed up-regulation of 16 genes in MDA-MB 231, six genes in MCF-7 and ERCC1, PNKP, MPG and RAD54L being upregulated in both MCF-7 and MDA-MB 231 cells.
Conclusion: Our results indicated that PAC significantly up-regulated multiple genes involved in the DNA repair pathway which certainly open new incites in cancer prevention and maintenance of genome stability. We suggest that PAC could use as a complementarytreatment for cancer protection by modulation of these genes.
Granch Berhe Tseghai
Producing Fire Retardant Cotton Fabric Using Chicken Eggshell
Granch Berhe Tseghai is a researcher in Chemistry from Kombolcha Institute of Technology
Cotton has poor fire retardance characteristics. Due the textile material is not recommended in areas of fire risks though it has high comfort factor; therefore imparting fire retardance is must to cotton. This research focuses on producing fire retardant cotton fabric using chicken eggshell to replace synthetic fire retardant chemicals. Chicken eggshell contains fire-retardant mineral such as calcium carbonate, phosphorous, nitrous, potassium and zinc. Imparting fire retardance using synthetic chemicals has many limitations; toxicity, environmental hazards, non biodegradable, non-renewable source and cost. On the other side chicken eggshell being bio-product has not any side effects since it occurs in nature abundantly. In most cases the chicken eggshell are removed after usage or hatching causing a big environmental pollution in appearance as well as in odor. Conversion of such wastes to treasure has a dual benefit in preventing cotton from burning extension and using the eggshell wastes for valuable treatment process. Treated fabric using chicken eggshell showed low flammability than untreated. In addition the treated fabric formed ash and char, whereas untreated fabric produced only ash and got totally burn. The fire propagations were 40 and 1.4 mm per second for untreated and treated fabrics respectively.